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The Things That Keep You Up at Night…

Once upon a time in pharmacy school, we were introduced to a table of antibiotic susceptibilities. Today, I am picking on cephalosporins for this reason and I roughly quote “these antibiotics appeared to lose activity against gram positive organisms and gain gram negative activity in each new generation…well sort of, but not completely so we leave the “+” sign on the antibiotic spectrum table of activity but it’s more complicated than.” It is indeed more complicated than that. Pathogen (resistance, MICs and intrinsic factors), drug (potency and distribution) and patient factors all need to be taken into consideration. One of my ID rotation goals was to bring some long over due order to this issue by creating a table of predicted susceptibilities based on Bugs and Drugs as a rough guide.

Streptococcal Coverage of Cephalosporins

 

 

 

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